2026

Immune cell-associated DNA methylation responses to exercise in women: A bioinformatics analysis comparing pre- and postmenopausal stages

Guilherme da Silva Rodrigues, Natalia Yumi Noronha, Andressa Crystine da Silva Sobrinho, Bernadette Jones-Freeman, Robin Grolaux, Camila Fernanda Cunha Brandao, Julio Sergio Marchini, Lígia Moriguchi Watanabe, Carla Barbosa Nonino, Andrew Teschendorff, Nir Eynon, Carlos Roberto Bueno Júnior, Macsue Jacques

Experimental Gerontology - February 2026

2025

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‚ÄêSu, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff

Advanced Science - August 2025

$Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age$

Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

Xiaolong Guo, Mahnoor Sulaiman, Alexander Neumann, Shijie C Zheng, Charlotte AM Cecil, Andrew E Teschendorff, Bastiaan T Heijmans

Genome Medicine - February 2025

Single-cell multi-stage spatial evolutional map of esophageal carcinogenesis

Jiang Chang, Junting Lu, Qingyi Liu, Tao Xiang, Shaosen Zhang, Yonglin Yi, Dongxu Li, Tianyuan Liu, Zeyuan Liu, Xinjie Chen, Zhenghao Dong, Cainan Li, HanZhang Yi, Siqi Yu, Luwei Huang, Fangfei Qu, Mengdi Wang, Dehe Wang, Hao Dong, Guoyu Cheng, Liang Zhu, Jiachen Li, Chenying Li, Pujie Wu, Xiaoting Xie, Andrew E. Teschendorff, Dongxin Lin, Xiaoqun Wang, Chen Wu

Cancer Cell - March 2025

Interpretable deep learning of single-cell and epigenetic data reveals novel molecular insights in aging

Zhi-Peng Li, Zhaozhen Du, De-Shuang Huang, Andrew E. Teschendorff

Scientific Reports - February 2025

Epigenetic clocks and inflammaging: pitfalls caused by ignoring cell-type heterogeneity

Xiaolong Guo, Andrew E. Teschendorff

Geroscience - January 2025

Epigenetic ageing clocks: statistical methods and emerging computational challenges

Andrew E. Teschendorff, Steve Horvath

Nature Reviews Genetics - January 2025

Distance covariance entropy reveals primed states and bifurcation dynamics in single-cell RNA-Seq data

Qi Luo, Alok K. Maity, Andrew E. Teschendorff

iScience - March 2025

An improved reference library and method for accurate cell-type deconvolution of bulk-tissue miRNA data

Shaoying Zhu, Hui Yang, Jun Liu, Qingsheng Fu, Wei Huang, Qi Chen, Andrew E. Teschendorff, Yungang He, Zhen Yang

Nature Communications - July 2025

2024

Universal penalized regression (Elastic-net) model with differentially methylated promoters for oral cancer prediction

Shantanab Das, Saikat Karuri, Joyeeta Chakraborty, Baidehi Basu, Aditi Chandra, S. Aravindan, Anirvan Chakraborty, Debashis Paul, Jay Gopal Ray, Matt Lechner, Stephan Beck, Andrew E. Teschendorff, Raghunath Chatterjee

European Journal of Medical Research - September 2024

Quantifying the stochastic component of epigenetic aging

Huige Tong, Varun B. Dwaraka, Qingwen Chen, Qi Luo, Jessica A. Lasky-Su, Ryan Smith, Andrew E. Teschendorff

Nature Aging - May 2024

On epigenetic stochasticity, entropy and cancer risk

Andrew E. Teschendorff

Philosophical Transactions of the Royal Society B: Biological Sciences - March 2024

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

Macsue Jacques, Shanie Landen, Adam P Sharples, Andrew Garnham, Ralf Schittenhelm, Joel Stele, Aino Heikkinen, Elina Sillanpaa, Miina Ollikainen, James Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekstrom, Olof Asplund, Severine Lamon, Sarah E. Alexander, Cassandra Smith, Carlie Bauer, Mary N. Woessner, Itamar Levinger, Andrew E Teschendorff, Linn Gillberg, Ida Blom, Jorn Wulff Helge, Nicholas R Harvey, Larisa M Haupt, Lyn R Griffiths, Atul S. Deshmukh, Kirsi H Pietilainen, Paivi Piirila, Robert AE Seaborne, Bernadette Jones-Freeman, Nir Eynon

Cell Report - July 2024

Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians

Wenran Li, Mingfeng Xia, Hailuan Zeng, Huandong Lin, Andrew E. Teschendorff, Xin Gao, Sijia Wang

Clinical Epigenetics - May 2024

Integrative Analysis of Genomic and Epigenomic Regulation Reveals MicroRNA Regulatory Network Mediated Tumor Heterogeneity and Immune Evasion in Lower Grade Glioma

Zhen Yang, Xiaocen Liu, Hao Xu, Andrew E. Teschendorff, Lingjie Xu, Jingyi Li, Minjie Fu, Jun Liu, Hanyu Zhou, Yingying Wang, Licheng Zhang, Yungang He, Kun Lv, Hui Yang

Communication Biology - January 2024

Computational single-cell methods for predicting cancer risk

Andrew E. Teschendorff

Biochemical Society Transactions - June 2024

Challenges and perspectives in computational devonvolution of genomics data

Lana X. Garmire, Yijun Li, Qianhui Huang, Chuan Xu, Sarah A. Teichmann, Naftali Kaminski, Matteo Pellegrini, Quan Nguyen, Andrew E. Teschendorff

Computational Molecular Biology - February 2024

Cell-type specific subtyping of epigenomes improves prognostic stratification of cancer

Qi Luo, Andrew E. Teschendorff

Genome Medicine - December 2024

Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution

Huige Tong, Xiaolong Guo, Macsue Jacques, Qi Luo, Nir Eynon, Andrew E. Teschendorff

Aging - November 2024

An improved epigenetic counter to track mitotic age in normal and precancerous tissues

Tianyu Zhu, Huige Tong, Zhaozhen Du, Stephan Beck, Andrew E. Teschendorff

Nature Communications - May 2024

A comprehensive map of the aging blood methylome in humans

Kirsten Seale, Andrew Teschendorff, Alexander P. Reiner, Sarah Voisin, Nir Eynon

Genome Biology - September 2024

2023

FORGEdb: a tool for identifying candidate functional variants and uncovering target genes and mechanisms for complex diseases

Charles E. Breeze, Eric Haugen, María Gutierrez-Arcelus, Xiaozheng Yao, Andrew Teschendorff, Stephan Beck, Ian Dunham, John Stamatoyannopoulos, Nora Franceschini, Mitchell J. Machiela, Sonja I. Berndt

Genome Biology - May 2023

Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq data

Alok Maity, Andrew Teschendorff

Nature Communications - June 2023

$A meta-analysis of immune cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes$

A meta-analysis of immune cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes

Qi Luo, Varun B. Dwaraka, Qingwen Chen, Huige Tong, Tianyu Zhu, Kirsten Seale, Joseph M Raffaele, Shijie C. Zheng, Tavis L. Mendez, Yulu Chen, Sofina Begum, Kevin Mendez, Sarah Voisin, Nir Eynon, Jessica A. Lasky-Su, Ryan Smith, Andrew E. Teschendorff

Genome Medicine - March 2023

2022

Novel epigenetic network biomarkers for early detection of esophageal cancer

Alok K. Maity, Timothy C. Stone, Vanessa Ward, Amy P. Webster, Zhen Yang, Aine Hogan, Hazel McBain, Margaraet Duku, Kai Man Alexander Ho, Paul Wolfson, David G. Graham, , Stephan Beck, Andrew E. Teschendorff, Laurence B. Lovat

Clinical Epigenetics - February 2022

Making sense of the ageing methylome

Kirsten Seale, Steve Horvath, Andrew Teschendorff, Nir Eynon, Sarah Voisin

Nature Reviews Genetics - May 2022

International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System

Matt Lechner, Yoko Takahashi, Mario Turri-Zanoni, Marco Ferrari, Jacklyn Liu, Nicholas Counsell, Davide Mattavelli, Vittorio Rampinelli, William Vermi, Davide Lombardi, Rami Saade, Ki Wan Park, Volker H Schartinger, Alessandro Franchi, Carla Facco, Fausto Sessa, Simonetta Battocchio, Tim R Fenton, Francis M Vaz, Paul O'Flynn, David Howard, Paul Stimpson, Simon Wang, S Alam Hannan, Samit Unadkat, Jonathan Hughes, Raghav Dwivedi, Cillian T Forde, Premjit Randhawa, Simon Gane, Jonathan Joseph, Peter J Andrews, Manas Dave, Jason C Fleming, David Thomson, Tianyu Zhu, Andrew Teschendorff, Gary Royle, Christopher Steele, Joaquin E Jimenez, Jan Laco, Eric W Wang, Carl Snyderman, Peter D Lacy, Robbie Woods, James P O'Neill, Anirudh Saraswathula, Raman Preet Kaur, Tianna Zhao, Murugappan Ramanathan Jr, Gary L Gallia, Nyall R London Jr, Quynh-Thu Le, Robert B West, Zara M Patel, Jayakar V Nayak, Peter H Hwang, Mario Hermsen, Jose Llorente, Fabio Facchetti, Piero Nicolai, Paolo Bossi, Paolo Castelnuovo, Amrita Jay, Dawn Carnell, Martin D Forster, Diana M Bell, Valerie J Lund, Ehab Y Hanna

Journal of Neurological Surgery Part B Skull Base - April 2022

Integrative analysis of 3604 GWAS reveals multiple novel cell type-specific regulatory associations

Charles E. Breeze, Eric Haugen, Alex Reynolds, Andrew Teschendorff, Jenny van Dongen, Qing Lan, Nathaniel Rothman, Guillaume Bourque, Ian Dunham, Stephan Beck, John Stamatoyannopoulos, Nora Franceschini, Sonja I. Berndt

Genome Biology - January 2022

Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation

Zhen Yang, Feng Xu, Andrew E. Teschendorff, Yi Zhao, Lei Yao, Jian Li, Yungang He

Frontiers in Molecular Biosciences - December 2022

Inference of age-associated transcription factor regulatory activity changes in single cells

Alok K. Maity, Xue Hu, Tianyu Zhu, Andrew E. Teschendorff

Nature Aging - June 2022

dbDEMC 3.0: Functional exploration of differentially expressed miRNAs in cancers of human and model organisms

Feng Xu, Yifan Wang, Yunchao Ling, Chenfen Zhou, Haizhou Wang, Andrew E Teschendorff, Yi Zhao, Haitao Zhao, Yungang He, Guoqing Zhang, Zhen Yang

Genomics Proteomics Bioinformatics - May 2022

Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022.

CNCB-NGDC Members and Partners

Nucleic Acids Research - January 2022

Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression

Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu

Cancer Research - July 2022

Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma

Matt Lechner, Yoko Takahashi, Mario Turri-Zanoni, Jacklyn Liu, Nicholas Counsell, Mario Hermsen, Raman Preet Kaur, Tianna Zhao, Murugappan Ramanathan Jr, Volker H Schartinger, Oscar Emanuel, Sam Helman, Jordan Varghese, Jozsef Dudas, Herbert Riechelmann, Susanne Sprung, Johannes Haybaeck, David Howard, Nils Wolfgang Engel, Sarah Stewart, Laura Brooks, Jessica C Pickles, Thomas S Jacques, Tim R Fenton, Luke Williams, Francis M Vaz, Paul O'Flynn, Paul Stimpson, Simon Wang, S Alam Hannan, Samit Unadkat, Jonathan Hughes, Raghav Dwivedi, Cillian T Forde, Premjit Randhawa, Simon Gane, Jonathan Joseph, Peter J Andrews, Gary Royle, Alessandro Franchi, Roberta Maragliano, Simonetta Battocchio, Helen Bewicke-Copley, Christodoulos Pipinikas, Amy Webster, Chrissie Thirlwell, Debbie Ho, Andrew Teschendorff, Tianyu Zhu, Christopher D Steele, Nischalan Pillay, Bart Vanhaesebroeck, Ahmed Mohyeldin, Juan Fernandez-Miranda, Ki Wan Park, Quynh-Thu Le, Robert B West, Rami Saade, R Peter Manes, Sacit Bulent Omay, Eugenia M Vining, Benjamin L Judson, Wendell G Yarbrough, Maddalena Sansovini, Nicolini Silvia, Ilaria Grassi, Alberto Bongiovanni, David Capper, Ulrich Schüller, Selvam Thavaraj, Ann Sandison, Pavol Surda, Claire Hopkins, Marco Ferrari, Davide Mattavelli, Vittorio Rampinelli, Fabio Facchetti, Piero Nicolai, Paolo Bossi, Oswaldo A Henriquez, Kelly Magliocca, C Arturo Solares, Sarah K Wise, Jose L Llorente, Zara M Patel, Jayakar V Nayak, Peter H Hwang, Peter D Lacy, Robbie Woods, James P O'Neill, Amrita Jay, Dawn Carnell, Martin D Forster, Masaru Ishii, Nyall R London Jr, Diana M Bell, Gary L Gallia, Paolo Castelnuovo, Stefano Severi, Valerie J Lund, Ehab Y Hanna

European Journal of Cancer - February 2022